KEMAL YELEKÇİ

Professor
 KEMAL YELEKÇİ

D BLOK 1. KAT 219

+90 (212) 533 65 32 / 1332

yelekci@khas.edu.tr

CV

https://www.kemalyelekci.com

ORCID

Education

Doctorate

OHİO UNIVERSITY
Organik Kimya

Master's Degree

ÇUKUROVA ÜNİVERSİTESİ
Organik Kimya

Bachelor's Degree

ORTA DOĞU TEKNİK ÜNİVERSİTESİ
Fen Edebiyat Fakültesi Kimya Bölümü

Research Areas

  • Bilgisayar Destekli İlaç Tasarımı
  • Moleküler Dinamik Simülasyon ve Doklama
  • Moleküler Modelleme ve Sanal İlaç Taraması
  • Sentetik Organik Kimya
  • Medisinal Kimya

Work Experience

2001 / Continuing Prof. Dr.
Kadir Has Üniversitesi, Moleküler Biyoloji ve Genetik

1990 / 2001 Prof. Dr., Doç. Dr.
Marmara Üniversitesi, Kimya Bölümü

1988 / 1989 Yrd. Doç. Dr.
Ege Üniversitesi, Kimya Bölümü

1987 / 1988 Doktora sonrası araştırmacı
Northwestern Üniversitesi, Medisinal Kimya Bölümü

Publications

  • "Repurposing of known drugs from multiple libraries to identify novel and potential selective inhibitors of HDAC6 via in silico approach and molecular modeling",
    Mert, Naz Mina; Erdogan, Buse; Yelekçi, Kemal; Heliyon, (2024) Vol.10, No.15, DOI: 10.1016/j.heliyon.2024.e35020
  • "Synthesis, in vitro and in silico studies on novel 3-aryloxymethyl-5-[(2-oxo-2-arylethyl)sulfanyl]-1,2,4-triazoles and their oxime derivatives as potent inhibitors of mPGES-1",
    Erensoy, Gizem; Ding, Kai; Zhan, Chang Guo; Çiftçi, Gamze; Yelekçi, Kemal; Duracık, Merve; Bingöl Özakpınar, Özlem; Aydemir, Esra; Yılmaz, Zübeyde Nur; Şahin, Fikrettin; Kulabaş, Necla; Tatar, Esra; Küçükgüzel, İlkay; Journal of Molecular Structure, (2023) Vol.1272, DOI: 10.1016/j.molstruc.2022.134154
  • "Computational Chemistry and Molecular Modeling of Reversible MAO Inhibitors"
    , Yelekçi, Kemal; Erdem, Safiye Sağ; Methods in Molecular Biology, Humana Press(2023)
  • "Synthesis and investigation of cytotoxic effects of compounds derived from flurbiprofen",
    Gökoğlan, Ecem; Dere, Damla; Bedir, İpek; Yelekçi, Kemal; Telci, Dilek; Küçükgüzel, Güniz; Journal of Molecular Structure, (2023) Vol.1289, DOI: 10.1016/j.molstruc.2023.135876
  • "Novel azole-urea hybrids as VEGFR-2 inhibitors: Synthesis, in vitro antiproliferative evaluation and in silico studies",
    Shirzad, Mohammad Musa; Kulabaş, Necla; Erdoğan, Ömer; Çevik, Özge; Dere, Damla; Yelekçi, Kemal; Danış, Özkan; Küçükgüzel, İlkay; Journal of Molecular Structure, (2023) Vol.1294, DOI: 10.1016/j.molstruc.2023.136448
  • "Synthesis and molecular modeling of MetAP2 of thiosemicarbazides, 1,2,4-triazoles, thioethers derived from (S)-Naproxen as possible breast cancer agents",
    Birgül, Kaan; Uba, Abdullah Ibrahim; Çuhadar, Ozan; Sevinç, Sevgi Koçyiğit; Tiryaki, Selen; Tiber, Pınar Mega; Orun, Oya; Telci, Dilek; Yılmaz, Özgür; Yelekçi, Kemal; Güniz Küçükgüzel, ; Journal of Molecular Structure, (2022) Vol.1259, DOI: 10.1016/j.molstruc.2022.132739
  • "Molecular modeling studies of some phytoligands from Ficus sycomorus fraction as potential inhibitors of cytochrome CYP6P3 enzyme of Anopheles coluzzii",
    Babandi, Abba; Anosike, Chioma A.; Ezeanyika, Lawrence U.S.; Yelekçi, Kemal; Uba, Abdullahi Ibrahim; Jordan Journal of Pharmaceutical Sciences, (2022) Vol.15, No.2, 258-275
  • "Potential inhibitors of methionine aminopeptidase type II identified via structure-based pharmacophore modeling",
    Albayati, Safana; Uba, Abdullahi Ibrahim; Yelekçi, Kemal; Molecular Diversity, (2022) Vol.26, No.2, 1005-1016 DOI: 10.1007/s11030-021-10221-7
  • "Screening of novel and selective inhibitors for neuronal nitric oxide synthase (nNOS) via structure-based drug design techniques",
    Boumezber, Sarah; Yelekçi, Kemal; Journal of Biomolecular Structure and Dynamics, (2022) DOI: 10.1080/07391102.2022.2054471
  • "Synthesis and evaluation of antiproliferative and mPGES-1 inhibitory activities of novel carvacrol-triazole conjugates",
    Demirbolat, İlker; Kulabaş, Necla; Gürboğa, Merve; Özakpınar, Özlem Bingöl; Çiftçi, Gamze; Yelekçi, Kemal; Liu, Jianyang; Jakobsson, Per Johan; Danış, Özkan; Ogan, Ayşe; Küçükgüze, İlkay; Organic Communications, (2022) Vol.15, No.4, 356-377 DOI: 10.25135/acg.oc.142.2212.2651
  • "Design, synthesis, molecular modeling, and bioactivity evaluation of 1,10-phenanthroline and prodigiosin (Ps) derivatives and their Copper(I) complexes against mTOR and HDAC enzymes as highly potent and effective new anticancer therapeutic drugs",
    Cetin, M. Mustafa; Peng, Wenjing; Unruh, Daniel; Mayer, Michael F.; Mechref, Yehia; Yelekci, Kemal; Frontiers in Pharmacology, (2022) Vol.13, DOI: 10.3389/fphar.2022.980479
  • "Novel 1,2,4-triazoles derived from Ibuprofen: synthesis and in vitro evaluation of their mPGES-1 inhibitory and antiproliferative activity",
    Bülbül, Bahadır; Ding, Kai; Zhan, Chang Guo; Çiftçi, Gamze; Yelekçi, Kemal; Gürboğa, Merve; Özakpınar, Özlem Bingöl; Aydemir, Esra; Baybağ, Deniz; Şahin, Fikrettin; Kulabaş, Necla; Helvacıoğlu, Sinem; Charehsaz, Mohammad; Tatar, Esra; Özbey, Süheyla; Küçükgüzel, İlkay; Molecular Diversity, (2022) DOI: 10.1007/s11030-022-10551-0
  • "Discovery of novel isoform-selective histone deacetylases 5 and 9 inhibitors through combined ligand-based pharmacophore modeling, molecular mocking, and molecular dynamics simulations for cancer treatment",
    Elmezayen, Ammar D.; Al-Obaidi, Anas; Yelekçi, Kemal; Journal of Molecular Graphics and Modelling, (2021) Vol.106, DOI: 10.1016/j.jmgm.2021.107937
  • "Structure-based virtual screening for novel potential selective inhibitors of class IIa histone deacetylases for cancer treatment",
    Elmezayen, Ammar D.; Kemal, Yelekçi; Computational Biology and Chemistry, (2021) Vol.92, DOI: 10.1016/j.compbiolchem.2021.107491
  • "New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors",
    Salgin-Goksen, Umut; Telli, Gokcen; Erikci, Acelya; Dedecengiz, Ezgi; Tel, Banu Cahide; Kaynak, F. Betul; Yelekci, Kemal; Ucar, Gulberk; Gokhan-Kelekci, Nesrin; Journal of Medicinal Chemistry, (2021) Vol.64, No.4, 1989-2009 DOI: 10.1021/acs.jmedchem.0c01504
  • "Homology modeling of human GABA-AT and devise some novel and potent inhibitors via computer-aided drug design techniques",
    Al-Obaidi, Anas; Elmezayen, Ammar D.; Yelekçi, Kemal; Journal of Biomolecular Structure and Dynamics, (2021) Vol.39, No.11, 4100-4110 DOI: 10.1080/07391102.2020.1774417
  • "Homology modeling and in silico design of novel and potential dual-acting inhibitors of human histone deacetylases HDAC5 and HDAC9 isozymes",
    Elmezayen, Ammar D.; Yelekçi, Kemal; Journal of Biomolecular Structure and Dynamics, (2021) Vol.39, No.17, 6396-6414 DOI: 10.1080/07391102.2020.1798812
  • "Synthesis, molecular modeling, in vivo study and anticancer activity against prostate cancer of (+) (S)-naproxen derivatives",
    Birgül, Kaan; Yıldırım, Yeliz; Karasulu, H. Yeşim; Karasulu, Ercüment; Uba, Abdullah Ibrahim; Yelekçi, Kemal; Bekçi, Hatice; Cumaoğlu, Ahmet; Kabasakal, Levent; Yılmaz, Özgür; Küçükgüzel, Güniz; European Journal of Medicinal Chemistry, (2020) Vol.208, DOI: 10.1016/j.ejmech.2020.112841
  • "Crystallographic structure versus homology model: a case study of molecular dynamics simulation of human and zebrafish histone deacetylase 10",
    Uba, Abdullahi Ibrahim; Yelekçi, Kemal; Journal of Biomolecular Structure and Dynamics, (2020) Vol.38, No.15, 4397-4406 DOI: 10.1080/07391102.2019.1691658
  • "Identification of potential inhibitors of human methionine aminopeptidase (type II) for cancer therapy: Structure-based virtual screening, ADMET prediction and molecular dynamics studies",
    Weako, Jackson; Uba, Abdullahi Ibrahim; Keskin, Özlem; Gürsoy, Attila; Yelekçi, Kemal; Computational Biology and Chemistry, (2020) Vol.86, DOI: 10.1016/j.compbiolchem.2020.107244
  • "Synthesis, anticancer activity on prostate cancer cell lines and molecular modeling studies of flurbiprofen-thioether derivatives as potential target of metap (Type ii)",
    Yılmaz, Özgür; Bayer, Burak; Bekçi, Hatice; Uba, Abdullahi I.; Cumaoğlu, Ahmet; Yelekçi, Kemal; Güniz Küçükgüzel, ; Medicinal Chemistry, (2020) Vol.16, No.6, 735-749 DOI: 10.2174/1573406415666190613162322
  • "Synthesis, in silico studies and cytotoxicity evaluation of novel 1,3,4-oxadiazole derivatives designed as potential mPGES-1 inhibitors",
    Erensoy, Gizem; Ding, Kai; Zhan, Chang Guo; Elmezayen, Ammar; Yelekçi, Kemal; Duracik, Merve; Bingöl Özakpinar, Özlem; Küçükgüzel, İlkay; Journal of Research in Pharmacy, (2020) Vol.24, No.4, 436-451 DOI: 10.35333/jrp.2020.187
  • "Drug repurposing for coronavirus (COVID-19): in silico screening of known drugs against coronavirus 3CL hydrolase and protease enzymes",
    Elmezayen, Ammar D.; Al-Obaidi, Anas; Şahin, Alp Tegin; Yelekçi, Kemal; Journal of Biomolecular Structure and Dynamics, (2020) 1-13 DOI: 10.1080/07391102.2020.1758791
  • "The design of potent HIV-1 integrase inhibitors by a combined approach of structure-based virtual screening and molecular dynamics simulation",
    Samorlu, Augustine S.; Yelekçi, Kemal; Ibrahim Uba, Abdullahi; Journal of Biomolecular Structure and Dynamics, (2019) Vol.37, No.17, 4644-4650 DOI: 10.1080/07391102.2018.1557559
  • "Homology modeling of human histone deacetylase 10 and design of potential selective inhibitors",
    Ibrahim Uba, Abdullahi; Yelekçi, Kemal; Journal of Biomolecular Structure and Dynamics, (2019) Vol.37, No.14, 3627-3636 DOI: 10.1080/07391102.2018.1521747
  • "Synthesis, molecular modeling, in vivo study, and anticancer activity of 1,2,4-triazole containing hydrazide–hydrazones derived from (S)-naproxen",
    Han, Muhammed; Bekçi, Hatice; Uba, Abdullahi I.; Yıldırım, Yeliz; Karasulu, Ercüment; Cumaoğlu, Ahmet; Karasulu, Hatice Y.; Yelekçi, Kemal; Yılmaz, Özgür; Küçükgüzel, Güniz; Archiv der Pharmazie, (2019) Vol.352, No.6, DOI: 10.1002/ardp.201800365
  • "Human dopamine transporter: the first implementation of a combined in silico/in vitro approach revealing the substrate and inhibitor specificities",
    Djikic, Teodora; Martí, Yasmina; Spyrakis, Francesca; Lau, Thorsten; Benedetti, Paolo; Davey, Gavin; Schloss, Patrick; Yelekci, Kemal; Journal of Biomolecular Structure and Dynamics, (2019) Vol.37, No.2, 291-306 DOI: 10.1080/07391102.2018.1426044
  • "Synthesis, molecular modelling and antibacterial activity against helicobacter pylori of novel diflunisal derivatives as urease enzyme inhibitors",
    Coşkun, Göknil Pelin; Djikic, Teodora; Kalaycı, Sadık; Yelekçi, Kemal; Şahin, Fikrettin; Güniz Küçükgüzel, ; Letters in Drug Design and Discovery, (2019) Vol.16, No.4, 392-400 DOI: 10.2174/1570180815666180627130208
  • "Examining the stability of binding modes of the co-crystallized inhibitors of human HDAC8 by molecular dynamics simulation",
    Uba, Abdullahi Ibrahim; Weako, Jackson; Keskin, Özlem; Gürsoy, Attila; Yelekçi, Kemal; Journal of Biomolecular Structure and Dynamics, (2019) DOI: 10.1080/07391102.2019.1615989
  • "Absolute configuration and biological profile of pyrazoline enantiomers as MAO inhibitory activity",
    Goksen, Umut Salgin; Sarigul, Sevgi; Bultinck, Patrick; Herrebout, Wouter; Dogan, Ilknur; Yelekci, Kemal; Ucar, Gulberk; Gokhan Kelekci, Nesrin; Chirality, (2019) Vol.31, No.1, 21-33 DOI: 10.1002/chir.23027
  • "Pharmacophore-based virtual screening for identification of potential selective inhibitors of human histone deacetylase 6",
    Uba, Abdullahi Ibrahim; Yelekçi, Kemal; Computational Biology and Chemistry, (2018) Vol.77, 318-330 DOI: 10.1016/j.compbiolchem.2018.10.016
  • "Identification of potential isoform-selective histone deacetylase inhibitors for cancer therapy: A combined approach of structure-based virtual screening, admet prediction and molecular dynamics simulation assay",
    Uba, Abdullahi Ibrahim; Yelekçi, Kemal; Journal of Biomolecular Structure and Dynamics, (2018) Vol.36, No.12, 3231-3245 DOI: 10.1080/07391102.2017.1384402
  • "Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening, molecular docking and dynamics simulation studies",
    Uba, Abdullahi Ibrahim; Yelekçi, Kemal; Computational Biology and Chemistry, (2018) Vol.75, 131-142 DOI: 10.1016/j.compbiolchem.2018.05.004
  • "Synthesis, anticancer activity, and molecular modeling of etodolac-thioether derivatives as potent methionine aminopeptidase (type II) inhibitors",
    Çoruh, Işıl; Çevik, Özge; Yelekçi, Kemal; Djikic, Teodora; Küçükgüzel, Güniz; Archiv der Pharmazie, (2018) Vol.351, No.3-4, DOI: 10.1002/ardp.201700195
  • "Investigation of synthesis, molecular modelling and monoaminoxidase inhibitor activity of a new 2-pyrazoline compound",
    Evranos-Aksöz, Begüm; Uçar, Gülberk; Yelekçi, Kemal; Turk Hijyen ve Deneysel Biyoloji Dergisi, (2018) Vol.75, No.3, 253-264 DOI: 10.5505/TurkHijyen.2018.59219
  • "Synthesis, molecular docking and anticancer activity of diflunisal derivatives as cyclooxygenase enzyme inhibitors",
    Coşkun, Göknil Pelin; Djikic, Teodora; Hayal, Taha Bartu; Türkel, Nezaket; Yelekçi, Kemal; Şahin, Fikrettin; Küçükgüzel, Güniz; Molecules, (2018) Vol.23, No.8, DOI: 10.3390/molecules23081969
  • "Design, Synthesis and hMAO Inhibitory Screening of Novel 2-Pyrazoline Analogues",
    Evranos-Aksoz, Begum; Ucar, Gulberk; Yelekci, Kemal; Combinatorial Chemistry and High Throughput Screening, (2017) Vol.20, No.6, 510-521 DOI: 10.2174/1386207320666170504114208
  • "Corrected Panel-Reactive Antibody Positivity Rates for Hypersensitized Patients in Turkish Population With Calculated Panel-Reactive Antibody Software",
    Karadeniz, S. T.; Akgul, S. U.; Ogret, Y.; Ciftci, H. S.; Bayraktar, A.; Bakkaloglu, H.; Caliskan, Y.; Yelekci, K.; Turkmen, A.; Aydin, A. E.; Oguz, F. S.; Carin, M.; Aydin, F.; Transplantation Proceedings, (2017) Vol.49, No.3, 445-447 DOI: 10.1016/j.transproceed.2017.01.032
  • "Exploration of the binding pocket of histone deacetylases: The design of potent and isoform-selective inhibitors",
    Uba, Abdullahi İbrahim; Yelekçi, Kemal; Turkish Journal of Biology, (2017) Vol.41, No.6, 901-918 DOI: 10.3906/biy-1701-26
  • "New Human Monoamine Oxidase A Inhibitors with Potential Anti- Depressant Activity: Design, Synthesis, Biological Screening and Evaluation of Pharmacological Activity",
    Evranos-Aksoz, Begum; Ucar, Gulberk; Tas, Sadik Taskin; Aksoz, Erkan; Yelekci, Kemal; Erikci, Acelya; Sara, Yildirim; Iskit, Alper Bektas; Combinatorial chemistry & high throughput screening, (2017) Vol.20, No.6, 461-473 DOI: 10.2174/1386207320666170504113158
  • "Drug design for CNS diseases: Polypharmacological profiling of compounds using cheminformatic, 3D-QSAR and virtual screening methodologies",
    Nikolic, Katarina; Mavridis, Lazaros; Djikic, Teodora; Vucicevic, Jelica; Agbaba, Danica; Yelekci, Kemal; Mitchell, John B.O.; Frontiers in Neuroscience, (2016) Vol.10, No.JUN, DOI: 10.3389/fnins.2016.00265
  • "Synthesis and Screening of Human Monoamine Oxidase-A Inhibitor Effect of New 2-Pyrazoline and Hydrazone Derivatives",
    Evranos-Aksöz, Begüm; Baysal, Ipek; Yabanoʇlu-Çiftçi, Samiye; Djikic, Teodora; Yelekçi, Kemal; Uçar, Gülberk; Ertan, Rahmiye; Archiv der Pharmazie, (2015) Vol.348, No.10, 743-756 DOI: 10.1002/ardp.201500212
  • "Cis-cyclopropylamines as mechanism-based inhibitors of monoamine oxidases",
    Malcomson, Thomas; Yelekci, Kemal; Borrello, Maria Teresa; Ganesan, A.; Semina, Elena; De Kimpe, Norbert; Mangelinckx, Sven; Ramsay, Rona R.; FEBS Journal, (2015) Vol.282, No.16, 3190-3198 DOI: 10.1111/febs.13260
  • "Flavonoids from sideritis species: Human monoamine oxidase (hMAO) inhibitory activities, molecular docking studies and crystal structure of xanthomicrol",
    Turkmenoglu, Fatma Pinar; Baysal, Ipek; Ciftci-Yabanoglu, Samiye; Yelekci, Kemal; Temel, Hamdi; Paşa, Salih; Ezer, Nurten; Çaliş, Ihsan; Ucar, Gulberk; Molecules, (2015) Vol.20, No.5, 7454-7473 DOI: 10.3390/molecules20057454
  • "Synthesis of some novel hydrazone and 2-pyrazoline derivatives: Monoamine oxidase inhibitory activities and docking studies",
    Evranos-Aksöz, Begüm; Yabanoǧlu-Çiftçi, Samiye; Uçar, Gülberk; Yelekçi, Kemal; Ertan, Rahmiye; Bioorganic and Medicinal Chemistry Letters, (2014) Vol.24, No.15, 3278-3284 DOI: 10.1016/j.bmcl.2014.06.015
  • "Aryl butenoic acid derivatives as a new class of histone deacetylase inhibitors: Synthesis, in vitro evaluation, and molecular docking studies",
    Eŝiyok, Peruze Ayhan; Seven, Ozlem; Eymur, Gülüzar; Tatar, Gamze Bora; Erden, Didem Dayangaç; Yelekçi, Kemal; Yurter, Hayat; Demir, Ayhan Sitki; Turkish Journal of Chemistry, (2014) Vol.38, No.2, 338-344 DOI: 10.3906/kim-1305-56
  • "In silico identification of novel and selective monoamine oxidase B inhibitors",
    Yelekçi, Kemal; Büyüktürk, Bora; Kayrak, Nurdan; Journal of Neural Transmission, (2013) Vol.120, No.6, 853-858 DOI: 10.1007/s00702-012-0954-0
  • "Evaluation of selective human MAO inhibitory activities of some novel pyrazoline derivatives",
    Salgin-Gökşen, Umut; Yabanoǧlu-Çiftçi, Samiye; Ercan, Ayşe; Yelekçi, Kemal; Uçar, Gülberk; Gökhan-Kelekçi, Nesrin; Journal of Neural Transmission, (2013) Vol.120, No.6, 863-873 DOI: 10.1007/s00702-013-0980-6
  • "Synthesis, molecular modeling, and in vitro screening of monoamine oxidase inhibitory activities of some novel hydrazone derivatives",
    Salgin-Gökşen, Umut; Gökhan-Kelekçi, Nesrin; Yabanoglu-Çiftci, Samiye; Yelekçi, Kemal; Uçar, Gülberk; Journal of Neural Transmission, (2013) Vol.120, No.6, 883-891 DOI: 10.1007/s00702-013-0968-2
  • "Insights into the binding mode of new N-substituted pyrazoline derivatives to MAO-A: Docking and quantum chemical calculations",
    Erdem, Safiye Saǧ; Türkkan, Seyhan; Yelekçi, Kemal; Gökhan-Kelekçi, Nesrin; Journal of Neural Transmission, (2013) Vol.120, No.6, 859-862 DOI: 10.1007/s00702-012-0950-4
  • "Power of inhibition activity screening and 3D molecular modeling approaches in HDAC 8 inhibitor design",
    Bora Tatar, Gamze; Tokluman, Tenzile Deniz; Yelekçi, Kemal; Yurter, Hayat; Turkish Journal of Chemistry, (2011) Vol.35, No.6, 861-870 DOI: 10.3906/kim-1107-34
  • "In silico design of novel and highly selective lysine-specific Histone demethylase inhibitors",
    Akdoǧan, Ebru Demet; Erman, Burak; Yelekçi, Kemal; Turkish Journal of Chemistry, (2011) Vol.35, No.4, 523-542 DOI: 10.3906/kim-1102-985
  • "Synthesis and molecular modeling of some novel hexahydroindazole derivatives as potent monoamine oxidase inhibitors",
    Gökhan-Kelekçi, Nesrin; Şimşek, Ö Özgün; Ercan, Ayşe; Yelekçi, Kemal; Şahin, Z. Sibel; Işik, Şamil; Uçar, Gülberk; Bilgin, A. Altan; Bioorganic and Medicinal Chemistry, (2009) Vol.17, No.18, 6761-6772 DOI: 10.1016/j.bmc.2009.07.033
  • "Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies",
    Bora-Tatar, Gamze; Dayangaç-Erden, Didem; Demir, Ayhan S.; Dalkara, Sevim; Yelekçi, Kemal; Erdem-Yurter, Hayat; Bioorganic and Medicinal Chemistry, (2009) Vol.17, No.14, 5219-5228 DOI: 10.1016/j.bmc.2009.05.042
  • "Histone deacetylase inhibition activity and molecular docking of (e)-resveratrol: Its therapeutic potential in spinal muscular atrophy",
    Dayangaç-Erden, Didem; Bora, Gamze; Ayhan, Peruze; Kocaefe, Çetin; Dalkara, Sevim; Yelekçi, Kemal; Demir, Ayhan S.; Erdem-Yurter, Hayat; Chemical Biology and Drug Design, (2009) Vol.73, No.3, 355-364 DOI: 10.1111/j.1747-0285.2009.00781.x
  • "New pyrazoline bearing 4(3H)-quinazolinone inhibitors of monoamine oxidase: Synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity",
    Gökhan-Kelekçi, Nesrin; Koyunoǧlu, Semra; Yabanoǧlu, Samiye; Yelekçi, Kemal; Özgen, Özen; Uçar, Gülberk; Erol, Kevser; Kendi, Engin; Yeşilada, Akgül; Bioorganic and Medicinal Chemistry, (2009) Vol.17, No.2, 675-689 DOI: 10.1016/j.bmc.2008.11.068
  • "Thermal rearrangement of 2-acetoxy-2,6,6-trimethylbicyclo[3.1.0]hexane: Theoretical elucidation of the mechanism",
    Erdem, Safiye Saǧ; Uyar, Fahriye; Karahan, Özlem; Yelekçi, Kemal; Journal of Molecular Structure: THEOCHEM, (2007) Vol.814, No.1-3, 61-73 DOI: 10.1016/j.theochem.2007.02.041
  • "Docking of novel reversible monoamine oxidase-B inhibitors: Efficient prediction of ligand binding sites and estimation of inhibitors thermodynamic properties",
    Yelekçi, K.; Karahan, Ö; Toprakçi, M.; Journal of Neural Transmission, (2007) Vol.114, No.6, 725-732 DOI: 10.1007/s00702-007-0679-7
  • "A computational study on the amine-oxidation mechanism of monoamine oxidase: Insight into the polar nucleophilic mechanism",
    Erdem, Safiye Saǧ; Karahan, Özlem; Yidiz, Ibrahim; Yelekçi, Kemal; Organic and Biomolecular Chemistry, (2006) Vol.4, No.4, 646-658 DOI: 10.1039/b511350d
  • "Docking studies on monoamine oxidase-B inhibitors: Estimation of inhibition constants (Ki) of a series of experimentally tested compounds",
    Toprakçí, Mustafa; Yelekçi, Kemal; Bioorganic and Medicinal Chemistry Letters, (2005) Vol.15, No.20, 4438-4446 DOI: 10.1016/j.bmcl.2005.07.043
  • "Computer modeling of oxygen containing heptylamines as monoamine oxidase inactivators",
    Erdem, Safiye Saǧ; Yelekçi, Kemal; Journal of Molecular Structure: THEOCHEM, (2001) Vol.572, No.1-3, 97-106 DOI: 10.1016/S0166-1280(01)00587-5
  • "Effect of the locus of the oxygen atom in amino ethers on the inactivation of monoamine oxidase B",
    Yelekçi, Kemal; Silverman, Richard B.; Journal of Enzyme Inhibition, (1998) Vol.13, No.1, 31-39 DOI: 10.3109/14756369809035825
  • "Observation of a flavin semiquinone in the resting state of monoamine oxidase B by electron paramagnetic resonance and electron nuclear double resonance spectroscopy",
    DeRose, Victoria J.; Woo, Jonathan C.G.; Hawe, William P.; Hoffman, Brian M.; Silverman, Richard B.; Yelekci, Kemal; Biochemistry, (1996) Vol.35, No.34, 11085-11091 DOI: 10.1021/bi960749f
  • "Electron Spin Resonance Studies of Monoamine Oxidase B. First Direct Evidence for a Substrate Radical Intermediate",
    Yelekci, Kemal; Lu, Xingliang; Silverman, Richard B.; Journal of the American Chemical Society, (1989) Vol.111, No.3, 1138-1140 DOI: 10.1021/ja00185a059
  • "Thermal Aromatization of Alkylidenecyclopentenes and Related Hydrocarbons",
    Huntsman, William D.; Pin Chen, Jom; Yelekci, Kemal; Yin, Tyze Kuan; Jian Zhang, Li; Journal of Organic Chemistry, (1988) Vol.53, No.18, 4357-4363 DOI: 10.1021/jo00253a031

Projects

Project Name Role in the Project Project Type Fund Establishment Start Date End Date
"CA20121 - Bench to bedside transition for pharmacological regulation of NRF2 in noncommunicable diseases" Yürütücü Uluslararası Proje COST 19.10.2021
 10.10.2025
"Kanser tedavisinde kullanılmak üzere histon deasetlaz HDAC6 ve HDAC10 enzimlerine karşı in siliko tarama ve medisinal kimya yaklaşımlarını kullanılarak etkili ve seçimli yeni inhibitörle" Yürütücü Ulusal Proje Diğer Ulusal 01.03.2020
 01.03.2022
"COST CM1406 Epigenetik Kimyasal Biyoloji (EPICHEM)/ Epigenetic Chemical Biology (EPICHEM)" Yürütücü Uluslararası Proje COST 13.11.2014
 18.11.2018
"FP7-PEOPLE-2013-ITN: Training in Neurodegeneration, Therapeutics Intervention & Neurorepair" Yürütücü Uluslararası Proje HORIZON 2020 01.10.2013
 30.09.2017
"Cost Action CM1103: Structure-based Drug Design for Diagnosis and Treatment of Neurological Diseases: Dissecting and Modulating Complex Function in the Monoaminergic System of the Brain." Yürütücü Uluslararası Proje COST 18.03.2013
 18.03.2015
"211 T100-TBAG: Nörodejenerative Hastalıkların Önlenmesine Yönelik In Silico Nöronal Nitrik Oksit Sentez (nNOS) Seçimli İnhibitör Tasarımı" Yürütücü Ulusal Proje TÜBİTAK ARDEB 01.02.2012
 01.03.2013
"108T232: Monoamin Oksidaz (MAO) Inhibitör Etkili Yeni Pirazolin Türevlerinin Moleküler Modelleme Yöntemiyle Tasarlanması, Sentezi ve Inhibisyon Kinetiklerinin Hesapsal ve Deneysel Olarak Tayi" Yürütücü Ulusal Proje TÜBİTAK Diğer 02.02.2008
 01.08.2010
"Project Reference 30005: MOBILITY-COMPIB-Characterisation of Mitochondrial Proteins in the Brain" Yürütücü Uluslararası Proje FP7 01.05.2006
 30.04.2010

Courses Offered

Course Name Course Code Period
Bioorganic Chemistry Lab II MBG222 2024/25 Spring
Genetics and Society MBG101 2024/25 Spring
Bioorganic Chemistry II MBG212 2024/25 Spring
Organic Chemistry of Drug Design and Drug Action MBG425 2024/25 Fall
Bioorganic Chemistry I MBG211 2024/25 Fall
Bioorganic Chemistry I MBG201 2024/25 Fall
Special Topics in Medicinal Chemistry BIO622*1 2024/25 Fall
Organic Chemistry of Drug Design and Drug Action MSN520 2024/25 Fall
Pharmacophore Modeling MBG319 2024/25 Fall